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Cholesterol Cholesterol Treatment

How Safe are Cholesterol Medications?


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Summary & Participants

It's important for those with high cholesterol to learn about the medications they may take to control it. Find out what the experts think about the most commonly used drugs.

Medically Reviewed On: July 11, 2006

Webcast Transcript


ANNOUNCER: For those with high cholesterol, a common concern is about the safety of the medications used to lower it.

SUZANNE HUGHES, MSN, RN: The medications that lower cholesterol are in general very, very safe. The largest group of drugs that most people have heard the most about are called the statins, and the statins have been on the market now since September of 1987, and they overall have a great safety record.

Now, these drugs are metabolized by the liver, and so it's necessary for a person taking these medications to have regular blood tests, not only to measure how effective the medications are in optimizing the cholesterol profile, but also to make sure that there aren't any adverse effects on the liver.

ANNOUNCER: Besides the possibility of affecting the liver, there are other considerations to keep in mind.

SPENCER B. KING, III, MD: There are some other potentially dangerous things like muscle aches that may lead to complications, kind of a flu-like feeling that can develop. But in general, the cholesterol-lowering drugs are very safe.

Sometimes we worry about any side effect of a drug, but in doing that we must also look at what the drug is doing in a positive way, and the cholesterol-modifying drugs are one of our most important breakthroughs in medicine. So no one should avoid the use of these drugs if they're indicated simply because of fear of some of these side effects.

ANNOUNCER: In addition to statins, there are other medications that can lower cholesterol.

SUZANNE HUGHES, MSN, RN: Another one is fibrates that generally operate not to lower the LDL, like the statins do, but to normalize the triglyceride and the HDL cholesterol. These are also very safe, although when used in combination with a statin do require a little more careful followup.

And another class of medications is the niacin group. And there's a prescription medicine that's niacin that actually can very nicely raise the HDL cholesterol and lower triglycerides.

And then the last main class is the bile acid sequestrants, a group of medicines that actually can lower the LDL cholesterol, and they are not processed through the liver. They just act entirely on the gastrointestinal system.

NANETTE KASS-WENGER, MD There's a new medicine on the scene called ezetimibe, which prevents the absorption of cholesterol, and this has been added to a statin to provide further cholesterol lowering. ANNOUNCER: With all the information available, patients with high cholestrol have many treatment options to consider with their physican.

NANETTE KASS-WENGER, MD: The most important thing is the benefit. No drug is absolutely safe, just as crossing the street is not absolutely safe. And when you decide to take a drug, or when I recommend that you take a drug, it really is because the benefits of this drug far, far, far, far outweigh any potential adverse effects.

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