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Multiple Sclerosis Multiple Sclerosis Treatment
Neutralizing antibodies may develop while a person is on interferon therapy which may render the drug less effective.
When a person receives interferon injections for about a year, he/she can develop antibodies against that interferon, much in the same way the body develops antibodies against influenza. With interferon being administered, particularly in the subcutaneous route, there is a higher likelihood that the body will develop antibodies that attack the injected interferon and neutralize it. That happens in about 35% of people on Betaseron, it happens in about 25% of people on Rebif and about 5% of people on Avonex for a year. Once neutralizing antibodies form, interferons are no longer effective and other therapeutic options are necessary.
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