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STDs Herpes

Can We Talk About Herpes? Again.


Medical Reviewer:

Anthony Vavasis, MD

Medically Reviewed On: June 23, 2006

Despite the onslaught of posters, TV commercials, public health officers and celebrities promoting safe sex over the last 20 years, rates of many sexual transmitted diseases in United States have been steadily rising. Even though about 20 percent of Americans have genital herpes, an estimated 90 percent of people infected with the virus don’t realize that they have it. And passing the virus unknowingly to unsuspecting partners may partially explain the increase in genital herpes rates.

Genital herpes can cause outbreaks involving painful blisters and flu-like symptoms, but symptoms can also be mild—and sometimes people don’t have any outward signs of infection. Not surprisingly, herpes is most often transmitted when people are not symptomatic. An equally worrisome feature researchers have discovered is that people with herpes are at a higher risk for getting and transmitting HIV.

Below, Dr. Anna Wald, an associate professor at the University of Washington and medical director of the Virology Research Clinic, provides an overview of the herpes simplex virus, which causes both oral and genital herpes.

What is herpes simplex?
Herpes simplex virus is one of eight known human herpes viruses. It belongs to a family of DNA viruses that have infected humans for a long time. One of the somewhat unique characteristics of herpes is the fact that it establishes latency in the host, meaning that once someone is infected, the virus stays in the body for the rest of your life.

Within the herpes simplex virus group, there are two types: herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2). Historically, herpes simplex 1 has been associated with cold sores or fever blisters on the mouth and lips. And HSV-2 has been thought to be the primary cause of genital herpes. However, because of oral-genital contact, doctors are also seeing quite a bit of genital HSV-1.

What are the symptoms?
Most people who have HSV-2 don’t know that they have genital herpes because they either have no symptoms or their symptoms are mild and infrequent. But classic symptoms, which are present in a minority of the people infected, are different with primary infection and what doctors call recurrences. The primary infection can be a major illness with fever, chills, flu-like symptoms and genital ulcerations. These often start as blisters and then they break down into ulcers, or sores. In many people, the lesions hurt a lot and are very tender to touch.

“With a recurrence what we see is also an outbreak of ulcerations,” says Wald, “but the outbreak is usually smaller and doesn’t last as long.”

But it’s also important to know that there is a phenomenon called asymptomatic shedding. This means that the virus can be present in the genital or oral tract on days in which there are no lesions, no ulcers. And that’s when most of the transmission occurs.

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